Inhibition in penicillin-induced epileptic foci
نویسندگان
چکیده
منابع مشابه
Inhibition in Penicillin - Induced Epileptic
As an acute model o f focal epi lepsy, the penicil l in focus has been wide ly ut i l ized since the initial r epo r t by Walker and J o h n s o n (1945) . However , the cellular mechanisms responsible for the epi leptogenic e f fec t o f penlci lhn remain poo r ly u n d e r s t o o d . A characterist ic fea ture o f penici l l ininduced epilept ic foci is the pa roxysma l depolar iz ing shift ...
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The aim of this study was to investigate the effects of levetiracetam (LEV) on penicillin-induced epileptiform activity in rats. Penicillin was applied intracerebroventricularly (icv) at a dose of 500 IU to induce epileptiform activity. LEV was given intraperitoneally (ip) at doses of 20, 40, 80 mg/kg before penicillin injection. This agent reduced epileptiform activity by decreasing spike freq...
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ژورنال
عنوان ژورنال: Electroencephalography and Clinical Neurophysiology
سال: 1979
ISSN: 0013-4694
DOI: 10.1016/0013-4694(79)90003-8